Preheat the oven to 400F. In a small bowl, combine 1 tbsp cinnamon, 1 tablespoon paprika, and 1/2 tbsp cayenne pepper. Sprinkle the seasoning over the butternut squash and roast for 25-30 minutes, or until the squash is easy to poke with a fork. Add the butternut squash to a food processor with 1 clove of garlic and blend until smooth and creamy, scraping down the sides as you go.
Meanwhile, bring a large pot of water to a boil with 1 tbsp of salt. Add the cavatappi and cook until just al dente. Set aside.
In a large non-stick skillet, heat 2 tbsps of butter and 1 tbsp of olive oil on medium heat. Add the panko and stir to combine. Arrange the panko in an even layer in the skillet and let it toast for 2-3 minutes until golden brown. Transfer to a plate or small bowl and set aside.
Using the same pan you used for the toasted panko, melt 6 tbsps of butter over medium heat. Whisk in the flour and milk, stirring until it begins to thicken. Reduce the heat to low and whisk in 1/4 tsp nutmeg, 1/4 tsp paprika, 1/8 teaspoon cayenne pepper, salt and pepper. Mix in the squash puree, stirring until fully combined. Gradually add both cheeses, stirring well to combine until cheese is completely melted.
Add the pasta to the cheese sauce and stir to combine. Mix in half the panko and sprinkle the rest on top with fresh chopped chives.
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Notes
Add more milk if you need to thin out the cream sauce.
If you don't have chives, you can also garnish with fresh parsley, oregano or crispy sage leaves.